Catalog Number - 70000-PG3

The 70000‑PG3 Diamond Hydride Guard Column Cartridge is a single‑cartridge replacement designed to protect 2.1 mm ID analytical HPLC columns from particulate matter, strongly retained contaminants, and sample‑matrix components that can degrade chromatographic performance and shorten column lifetime.

This cartridge is intended for laboratories that prefer individual guard cartridge replacement, including workflows that use multiple stationary phases or where guard usage varies by method.

Guard Cartridge Use Case: Preserving Analytical Separations

Guard cartridges act as a sacrificial stationary phase bed, capturing contaminants before they reach the analytical column.

Critical Requirement: To preserve chromatographic fidelity, the stationary phase in the guard cartridge must match the stationary phase of the analytical column.

The Diamond Hydride chemistry used in this cartridge ensures:

• No change in retention mechanism

• No loss of resolution

• No selectivity shift

• No peak shape distortion

Using a guard cartridge with a mismatched chemistry can erode separation efficiency and compromise analytical results.

Construction & Cartridge Design

Each Diamond Hydride guard cartridge features:

• Stainless steel tube construction for pressure stability

• Stainless steel frits for uniform flow distribution

• Diamond Hydride stationary phase, 4 µm particle size, 100 Å pore size

• Individual labeling for traceability

Each cartridge is shipped in a resealable black Delrin case to protect against drying, contamination, or physical damage prior to installation.

Analytical Column Compatibility

The 70000‑PG3 guard cartridge is designed for use with:

• 2.1 mm ID analytical HPLC columns

• Cogent TYPE‑C™ Diamond Hydride analytical columns

• HILIC and LC‑MS methods requiring retention‑mechanism consistency

A compatible Cogent TYPE‑C™ guard column holder is required and sold separately.

Guard Column Installation Best Practices

To maintain chromatographic efficiency, the guard cartridge should be installed as close to the analytical column inlet as physically possible.

Excess tubing length between the guard and analytical column introduces extra‑column (dead) volume, which can result in:

• Band broadening

• Reduced theoretical plates

• Loss of resolution

• Peak tailing or distortion

When installed immediately upstream of the analytical column and paired with matching Diamond Hydride chemistry, the guard cartridge provides effective protection without degrading the separation.

Purpose‑Built for Column Protection & Flexible Use

The 70000‑PG3 single‑cartridge format is commonly selected for:

• Method development environments

• Multi‑chemistry laboratories

• Low‑to‑moderate guard replacement frequency

• Situations where individual cartridge control is preferred

Proper guard cartridge use can significantly extend analytical column lifetime, reduce downtime, and support long‑term method reproducibility.

System Requirements

• Requires a Cogent TYPE‑C™ guard column holder (sold separately)

• Compatible with standard analytical HPLC systems

• No method modifications required when stationary phases are properly matched